Why Still No SARS Coronavirus Vaccine?

Posted by Ed 37 days ago
Feds Race to Make SARS Vaccine

Developing a vaccine often takes a couple of decades or longer, but the federal government is aiming to develop a SARS vaccine in just three years. Scientists at the Vaccine Research Center are attacking the problem on several fronts, although some question whether a SARS vaccine is even possible.

FIFTEEN OR 20 years to create a new vaccine is considered quite speedy. So the federal government's blueprint for a shot to stop the SARS epidemic in a mere three years seems positively head-snapping.

Can it be done?

Certainly, says Dr. Gary Nabel, chief of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases. "If everything went perfectly," he qualifies. "If all the stars were aligned."

The stars almost never align precisely in medical research. But if they do, Nabel says scientists will finish all the basic lab work, creating the vaccine and testing it in animals, in just one year.

Then they will spend two more trying it out on people to make sure it works, turn the results over to the Food and Drug Administration and be done.

No vaccine in modern times has gone from start to finish nearly that fast. But even if Nabel's time line proves unrealistic, his willingness to state it out loud shows how seriously the government takes SARS.

The strategy for changing the pace from glacial to galactic: Forget solving problems one at a time.

"We need a vaccine. There's no question about it," says Dr. Anthony Fauci, head of the infectious disease institute. "This is potentially disastrous enough that we can't just hope it will go away and stay away."

Labs from Hong Kong to Canada are also tackling SARS vaccines, and Fauci said his institute will sign contracts with up to a dozen companies to help with development.

At this point, however, the single biggest question is still unanswered: Is a SARS vaccine even possible?

Dr. Emilio Emini, head of vaccine development at Merck, is among those trying to answer this. For now he refuses even to chance a guess.

"This is a new virus. So much is not understood," he says. "It's a big black box."

Worry that a vaccine will be too dangerous is one reason development takes so long. No one wants to make healthy people sick by giving them shots intended to prevent illness. So typically vaccines are tested painstakingly on thousands of volunteers over many years to prove they do far more good than harm.

Even with this, dangers may come to light only when they get into routine use. Four years ago, the first rotavirus vaccine was pulled from the market after just one year. The shots prevent childhood diarrhea, but they also turned out to cause life-threatening bowel obstructions in one in 10,000 recipients.

Scientists are especially cautious because of their experience with vaccines aimed at animal relatives of the SARS virus. SARS is a coronavirus, the same virus family that causes serious diseases in pigs and other animals. While shots work well against some of these, they occasionally go disastrously bad. A vaccine for the feline coronavirus actually results in worse disease, not less, when cats catch the virus.

Vaccines work by giving the body a glimpse of its target, typically a dead virus, a weakened live one or bits of viral proteins. When all goes well, the immune system remembers these and goes on full attack when it later encounters the real thing.

But as happened with the cat vaccine, they sometimes trigger an off-kilter immune reaction, so when attacked by the actual virus, the system responds with a weak or misguided defense.

Because the attenuated viruses cause true infections, they trigger an especially robust and well-rounded defense, arming the immune system to launch both antibodies and virus-killing T cells. But there are drawbacks: They can take a long time to make, and the crippled virus can theoretically mutate to regain its power, making people sick.

"They are effective but dangerous, and it will take a long time to get one we would give to people," says Picker.

Vaccines based on genetic engineering may be faster.

One approach is using gene-splicing to make plenty of SARS virus parts, such as the protein prongs that stick out from the virus, giving it a crown-like appearance under a microscope. Injecting these proteins -- but not the virus itself -- may be enough to prompt the immune system to recognize the SARS virus.

Even if one of these approaches quickly shows promise, it still must be pushed through human testing in a part of the world where SARS is spreading or, if SARS disappears, go through extensive animal testing. Some doubt all this can be accomplished quickly.

"Could the rules get changed so it would take less than 15 years? Yes. But could it be three years?" asks Dr. Donna Ambrosino, head of Massachusetts Biologic Laboratory, a nonprofit vaccine maker.

Doubtful, she says. There are simply too many unknowns, both about the virus itself and the safety of any strategy to stop it. She notes that scientists have been trying since the 1960s to make a vaccine for another breathing infection, the respiratory syncytial virus, which causes serious disease in babies.

"We know the proteins. We know the antibodies. We have animal models. We know all of that," she says. "But we still don't have a vaccine that works."

https://www.wired.com/2003/05/feds-race-to-make-sars-vaccine/ on this topic.

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Ed 36 days ago
Talk to your Twitter Mob to find out if the Covid vaccine is right for you…
Before committing heresy today and subjecting myself to the unforgiving courts of cancel culture, I’m compelled to state that I am not an ‘anti-vaxxer’.

Now, we live in a world where when you say you’re NOT something, you’re immediately guilty of being exactly that thing.

But the facts speak for themselves; even in my early 40s I still occasionally get vaccinated. Last year I tried a flu shot (though I still got the flu).

And since I spend a lot of time on a farm where rusty metals seem to grow out of the dirt, one of my physicians advised me to get a tetanus shot, which I did.

Some past vaccines have performed near miracles for human civilization. And I’m impressed by the brilliance of medical researchers and biochemists who developed these Covid vaccine candidates in record time.

I also think it’s poetic justice that the same Marxists who spent years threatening to nationalize the big drug companies are now singing their praises.

So I am in no way anti-vaccine.

(Though I do think the CDC’s recommendations to stick babies with dozens of shots before the age of 2 go a bit too far…)

I am, however, pro-freedom. And that includes the freedom to ask intelligent questions without ridicule.

For the last several weeks we’ve been hearing a steady stream of propaganda from the mainstream media insisting that ‘the COVID-19 vaccine is safe and effective’. And that’s been echoed by people shrieking the same refrain on Twitter over and over again.

I find this intriguing because it communicates a complete lack of understanding of basic facts.

For starters, there’s no such thing as “the” vaccine. There are multiple vaccines with multiple technologies, from Moderna’s ‘messenger RNA’ vaccine, to Shenzhen GenoImmune’s ‘dendritic cell’ vaccine.

More importantly, however, when the armchair immunologists on Twitter insist that ‘the vaccine is safe and effective,’ they don’t even realize that there is very little published research about the vaccines.

The US government’s public repository of clinical trial data for all drugs and vaccines, for example, does not publish current, detailed results for most Covid vaccine candidates.

And on Moderna’s own website, which had a special page set up for vaccine ‘data’, corporate executives instead chose to dazzle visitors with bombastic drivel about their diversity and inclusion, rather than publish actual research results.

Yet the media and Twitter mob continued to howl that ‘the vaccine is safe and effective’ despite limited published research.

Dr. Fauci said the vaccine was safe, and of course he never lies. The media latched on to this immediately without any further questioning. But isn’t it their job to ask questions?

Well, clearly not anymore. The media (and Twitter) only care to prevent others from asking questions and to ridicule anyone who commits the heresy of expressing concern.

These are the same people who are vocal about a woman’s ‘right to choose’. Yet they’re now calling for mandatory vaccination.

So abortions are just fine, but wanting to understand the vaccine more before rolling up your sleeve makes you a murderer.

And even more ridiculous, most people dispensing this wisdom from their ivory Twitter towers haven’t seen a scrap of data about any vaccine candidate.

They just keep screaming the same line over and over again that ‘the vaccine is safe and effective,’ because if you say something enough times, it becomes true.

They’ve been saying this for weeks. CNN was already running stories back in October slamming people who might express concern over a vaccine as ‘conspiracy theorists’.

And yet it was only a few days ago that the FDA released a 53 page report on Pfizer’s now-approved vaccine candidate. (CNN must be psychic…)

I’ll discuss this more later in the week, but overall the results are encouraging from an efficacy perspective: only 8 people out of the roughly 20,000 study participants who received the Pfizer’s BNT162b2 vaccine candidate ended up acquiring COVID-19.

But at the same time, the research does present some interesting safety results, stating clearly that “a higher proportion of vaccine recipients reported adverse events compared with placebo recipients…”

These adverse events among vaccine recipients included Bell’s palsy (a rare facial paralysis) that the study recommends monitoring, plus a disorder of the lymph nodes called lymphadenopathy that was “plausibly related to the vaccination.”

And ironically, a majority of the 20,000+ vaccine recipients acquired COVID-like symptoms, including fatigue, headache, nausea, fever, and chills.

There’s also an entire section in the report dedicated to what they still don’t know about the vaccine, including whether it even remains effective beyond two months.

(Remember, the FDA awarded Pfizer an ‘emergency authorization’, i.e. a short-circuited process that didn’t follow the normal scrutiny, so there’s a lot more testing to do.)

I’m in no way writing to sway anyone to take/not take the vaccine. I merely believe in knowledge and informed consent. And I’d suggest everyone read the FDA report for themselves.

Is it really so unreasonable that people should have the chance to discuss the vaccine trial results with their physicians before making a personal, medical decision?

US television networks run pharmaceutical advertisements all day, every day, covering every possible condition. Enlarged prostate. High blood pressure. Erectile dysfunction.

The commercials are totally bizarre– some couple walking on a beach while a background voice reads off a never-ending list of possible adverse side effects.

And in the end, the voice always concludes with the same message: “Talk to your doctor to find out if [insert catchy drug name] is right for you.”

You can’t even take an erectile dysfunction pill without consulting your physician. But with regards to the vaccine, you’re not allowed to ask any questions or raise any potential concerns. This is heresy.

With regards to Covid, we’re only allowed to receive medical advice from Twitter.

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Ed 29 days ago
Health Care Workers 'Are Afraid of the Covid Vaccine'
Administrators at Howard University Hospital in Washington, D.C., were thrilled to be among the city’s first hospitals to get a COVID-19 vaccine, but they knew it could be a tough sell to get staffers to take the shot.

They were right.

The hospital, located on the campus of one the nation’s oldest historically Black colleges, received 725 doses of the vaccine made by Pfizer and BioNTech on Dec. 14 and expects 1,000 more vaccine doses this week to immunize its workers.
Yet, as of Friday afternoon, about 600 employees had signed up for the shots, touted as about 95% effective in preventing the deadly disease. Howard has about 1,900 employees, not counting hundreds of independent contractors it also hoped to vaccinate.
“There is a high level of mistrust and I get it,” said Anita Jenkins, the hospital’s chief executive officer who received the shot Tuesday in hopes of inspiring her staff to follow her lead. “People are genuinely afraid of the vaccine.”

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Ed 27 days ago
WHO Deletes Naturally Acquired Immunity from Its Website

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Ed 12 days ago
A Healthy Miami Doctor Dies After Receiving First Dose Of Pfizer Vaccine

A doctor in Miami has died two weeks after receiving his first dose of the Pfizer-BioNTech jab.

The love of my life, my husband Gregory Michael MD an Obstetrician that had his office in Mount Sinai Medical Center in...
Heidi Neckelmann, the widow of Dr. Gregory Michael, said her husband was vaccinated on Dec. 18, and died 16 days later. He was 56 years old, according to Sputnik. Patients typically receive a second dose of the vaccine 3 weeks after the first. Neckelmann also shared the news in a Facebook post, cited above.

"In my mind his death was 100 percent linked to the vaccine. There is no other explanation," she said. "He was in very good health. He didn’t smoke, he drank alcohol once in a while but only socially. He worked out, we had kayaks, he was a deep sea fisherman," she added.
What's more, the doctor started to experience unusual symptoms, and three days after vaccination, small spots began to appear on Gregory Michael's feet and hands.
In response, he went to the emergency room at Mount Sinai. As his blood count was not in the normal ranges, he was admitted to the ICU, his wife told Sputnik. Shortly after, he suffered a stroke and died.
Three days after vaccination, small spots began to appear on Gregory Michael’s feet and hands. In response, he went to the emergency room at Mount Sinai. As his blood count was not in the normal ranges, he was admitted to the intensive care unit, according to Heidi Neckelmann. Unfortunately, shortly after, he suffered a stroke and died.
According to Darren Caprara, director of operations at the Miami-Dade medical examiner’s office, Gregory Michael's death is the first that the county medical examiner's office has seen where a COVID-19 vaccine could have played a role.
Earlier, Carlos Palestino, the brother-in-law of Mexican doctor Karla Cecilia Perez, was paralyzed hours after receiving the Pfizer/BioNTech COVID-19 vaccine, according to reports.

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