I tried Duromine, you can buy it from some pharmacies without prescription here!
But would definately not recommend it. Its just speed! I had one and threw the rest away. Duromine is the strongest on the market I think. The 40mg slow release pills are quite intense. I had a come down when it wore off!!!
All appetite suppresants in modern western medicine work by effecting the central nervous system to speed up the metabolism. Its the best they can offer us. There is a new "wonder drug" coming out later this year by a French pharmacuticl company. Its supposed to help stop cravings for cigarettes and alchol too.
The best approach is still to take responsibility and control over your life rather than solve your problems by taking pills.
Otherwise you could try Orlistat (sold as Xenical). It breaks down 30% of the fat you eat. It also stops the absorbtion of all the good stuff too, so you need to take vitamins at the right time as well. It doesn't have any speed in it and doesn't do anything to your central nervous system.
You could try HGH too.. there's another thread about it on this site... If your doctor prescribes it to you (unlikely).
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HGH will speed up your metabolism but it occurs naturally in your body, wont make you feel like you're on speed (i.e. with side effects of nervousness, tension, .... or feeling "weird")
You have to be careful with it and it requires injections :(
L-Carnatine helps you burn fat at the gym. Ive heard hydroxytea (which is like trademarked version of a recipe based on chinese herbal weight loss tea) is apparently effective. I cant vouch for either of these as I have not tried them or researched them much.