Does Vitamin D Improve the Survival of Cancer Patients?

Posted by Ed 8 mths ago
Purpose of review: Clinical evidence suggesting the beneficial effects of vitamin D on survival of patients with cancer has been accumulating. Recent articles were thoroughly reviewed to determine if there is enough evidence to conclude that vitamin D supplementation improves survival of patients with cancer.

Recent findings: Meta-analyses of observational studies showed that higher blood 25-hydroxyvitamin D levels in patients with cancer at a variety of sites were associated with lower cancer-specific and overall mortalities. Moreover, meta-analyses of randomized clinical trials (RCTs) also suggested that vitamin D supplementation improved the survival of patients with cancer.
However, each RCT used in these meta-analyses, as well as very recent RCTs, e.g., the SUNSHINE and the AMATERASU trial, did not show statistical significance in the primary results.
For now, compelling evidence that vitamin D supplementation effectively improves survival of patients with cancer is lacking. Thus, confirmatory RCTs are still obligatory for the future. 

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Ed 8 mths ago
According to Holick, it is important to recognize that most of the studies that have shown that vitamin D3 supplementation improves cancer survival provided patients with at least 2000 IUs vitamin D3. This amount of vitamin D3 substantially improves the vitamin D status (serum concentration of 25-hydroxyvitamin D) to a concentration above 30 ng/mL. 

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