Long-Term Use Of Statins Linked To Heart Disease: Studies

Posted by Ed 7 mths ago

For decades, statins have been heralded as the reliable heroes in the battle against heart disease, the leading cause of death in the United States and globally. However, this seemingly flawless reputation has been called into question.

A new expert review suggests that long-term use of statins may be inadvertently aiding the enemy by accelerating coronary artery calcification instead of providing protection.

The review, published in Clinical Pharmacology, suggests statins may act as “mitochondrial toxins,” impairing muscle function in the heart and blood vessels by depleting coenzyme Q10 (CoQ10), an antioxidant cells use for growth and maintenance. Multiple studies show statins inhibit CoQ10 synthesis, leading many patients to supplement.


CoQ10 is vital for producing ATP, the cell’s fundamental energy carrier. Insufficient CoQ10 inhibits ATP production, resulting in an energy deficit that the review authors say “could be a major cause for heart muscle and coronary artery damage.


We believe that many years of statin drug therapy result in the gradual accumulation of mitochondrial DNA damage,” according to the authors.


A 2022 study published in Biophysical Journal linked reduced ATP to heart failure.


A 2008 study published in BioFactors reaffirms the statin–CoQ10 link. Researchers evaluated 50 statin patients for side effects like fatigue and muscle pain. All then stopped statins and supplemented CoQ10 for 22 months on average.


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