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The Hapsburgs are one of those royal families who are relatively well known, and in the minds of the public are to a great extent the emblems of the downsides of inbreeding. In the painting above is Charles II, king of Spain, the last of the Spanish Hapsburgs, and an imbecile whose premature death at the age of 39 ushered in a period of dynastic chaos which led to the War of Spanish Succession.
These conflicts between France and other European powers were one of those turning points in history, a sad capstone to the long reign of the Sun King, Louis the XIV. France’s position as the unchallenged power of Europe ended due to the fiscal and military overextension necessitated by Louis’ war to secure the Spanish throne for his grandson.
But this a story of genetics as well as history, because historians have long assumed impressionistically that there was something rotten in the gene pool of the Spanish Hapsburgs. Here is an excerpt from an online biography of Charles II:
The Habsburg King Carlos II of Spain was sadly degenerated with an enormous misshapen head. His Habsburg jaw stood so much out that his two rows of teeth could not meet; he was unable to chew. His tongue was so large that he was barely able to speak. His intellect was similarly disabled. His brief life consisted chiefly of a passage from prolonged infancy to premature senility.
Carlos’ family was anxious only to prolong his days and thought little about his education, so that he could barely read or write. He had been fed by wet nurses until the age of 5 or 6 and was not allowed to walk until almost fully grown. Even then, he was unable to walk properly, because his legs would not support him and he fell several times.
His body remained that of an invalid child. The nature of his upbringing, the inadequacy of his education, the stiff etiquette of his court, his dependence upon his mother and his superstition helped to create a mentally retarded and hypersensitive monarch.
https://www.discovermagazine.com/the-sciences/inbreeding-and-the-downfall-of-the-spanish-hapsburgs#.Vpj2iXvKKSM